In the management of Vomiting & Nausea
Each film coated tablet contains:
Ondansetron – 4mg
It is a potent highy selective antagonist at the5hydroxytryptamine receptors sbtype3 (5HT3). It can effectively control vomiting due to anticancer drugs as well as raiotherapy. Unlike metoclopramide, ondansetron is not a lopomide antagonist and doen’t cause dystonia or extra pyramidal effects. It is a carbazole which causes antinauseant &antiemetic effects by selective & competitive blockade of the 5HT3 receptors.
Indication of ONDANSETRON:
Vomiting and nausea associated with cytoxic radiotherapy & chemotherapy, prophylaxi & treatment of postoperative vomiting and nausea.
Liver diseases, constipation, headache. Paediatrics: Reduced dose necessary. Not recommended below the age of 4 years. Pregnancy: Safety not established. use only, if clearly indicated. Lactation: The drug passes into breast milk. Elderly: No special problem.
Headache,constipation, sensation of flushing in the head and epigastrium, rarely allergic reactions.
Dexamethasone enhances the effect of the drug.
Pack (10×10 Tab)