Rabeprazole 20mg, Itopride 150mg
Packing Size – (10×10)

Don’t Allow REFLUX to come Back Ever

Each film coated capsule contains:
Rabeprazole 20mg, Itopride 150mg (SR)

It belongs to the class of antisecretory compounds, the substituted benzimidazoles, that suppress gastric acid secretion by the specific inhibition of the H+/K+-ATPase enzyme at the secretory surface of the gastric parietal cell and hence are called proton pump blockers.

Indication of RABEPRAZOLE:
Rabeprazole is indicated for the treatment of active duodenal ulcer. Active benign gastric ulcer. Symptomatic erosive or ulcerative gastro-oesophageal reflux disease (GORD). H.Pylori-positive duodenal ulcers, as part of the eradication programme with appropriate antibiotics, maintenance treatment of healed erosive or ulcerative GORD. Efficacy has not been demonstrated for periods exceeding 12 months.

Hypersensitivity, Pregnancy and lactation.

Special Precautions
Gastric or oesophageal malignancy should be excluded prior to commencing treatment with rabeprazole.

Side Effects
Headache, diarrhoea and nausea, rhinitis, abdominal pain, asthenia, flatulence, pharyngitis, vomiting, non-specific pain/back pain,, dizziness, flu syndrome, infection, cough, constipation and insomnia.

Drug Interactions
Co-administration of rebeprazole sodium results in a 33% decrease in ketoconazole levels and a 22% increase in trough digoxin levels in normal subjects.

Itopride inhibits the dopamine D2 receptor at the parasympathetic nerve ends and thereby increases the release of acetycholine and decreases the metabolism of acetylcholine by inhibiting the enzyme acetylcholinesterase (AChE). By maintaining higher acetylcholine levels, itopride increases the esophageal and gastrointestinal peristalsis, increases the lower esophageal sphincter pressure, stimulates gastric motility, accelerates gastric emptying and improves gastro-duodenal coordination. Because of its dopamine D2 receptor antagonistic action, it also exerts anti-emetic actions.

Treatment of gastrointestinal symptoms caused by reduced gastrointestinal motility such as feeling of gastric fullness, epigastric pain, anorexia, heartburn, regurgitation, bloating, nausea and vomiting.

Special Precautions
Should be used with caution as it enhances the action of acetylcholine.

Side Effects
Diarrhoea, constipation, headache, abdominal pian, irritated feeling and dizziness.

Drug Interactions
Cisapride, atropine.

Pack (10×10 Cap)

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