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Each Film coated tablet contains:
Aceclofenac 100mg, Thiocolchicoside 4mg
It is a phenyl acetic acid derivative showing effective anti-inflammatory and analgesic properties, and a good tolerability profile in a variety of painful conditions. Aceclofenac has been shown to exert effects on many mediators of inflammation. It inhibits synthesis of the inflammatory cytokines interleukin-1b and tumour necrosis factor, and inhibits prostaglandin E2 production. In vitro data indicate inhibition of cyclo-oxygenase by aceclofenac in whole blood assays, with selectivity for COX-2 being evident. A unique feature of aceclofenac’s pharmacology is that it, unlike diclofenac and some other NSAIDs, stimulates glycosaminoglycans (GAG) synthesis.
Indications of ACECLOFENAC:
For the relief of pain and inflammation in osteoarthritis, rheumatoid arthritis and ankylosing spondylitis.
Hypersensitivity, GI bleeding, moderate to severe renal impairment, last three months of pregnancy
Patients with GI disease, history of peptic ulceration, cerebrovascular bleeding, ulcerative colitis, Crohn’s disease, systemic lupus erythmatosus, porphyria, hematopoietic or coagulation disorders. The dose should be reduced in patients with mild to moderate hepatic, renal or cardiac function impairment.
Indigestion, heartburn, dyspepsia, diarrhoea, nausea, abdominal pain and flatulence.
Aceclofenac may increase the plasma conc. of lithium and digoxin. Aceclofenac may inhibit the activity of diuretics. Activity of anticoagulants may be enhanced. Convulsions may occur due to interaction between quinolones and NSAIDs.
It belongs to colchicine class. It has muscle relaxant, antiinflammatory, analgesic, and anesthetic action with minimal side effects. Rapidly onset of action is another unique feature of this drug. Its pharmacokinetic profile and metabolism still remain largely unknown.
Indications of THIOCOLCHICOSIDE:
Thiocolchicoside is primarily indicated in conditions like Backache, Neuralgia, Pain, Parkinsonism, Sciatic pain.
Allergic to Thiocolchicoside Hypersensitivity to Thiocolchicoside Peptic ulcer Acute Rhinitis Asthma If you have allergy towards Aceclofenac Breastfeeding Pregnant
Avoid driving and operate dangerous machinery, Gastro-intestinal disorders, History of gastroulceration, Limit alcoholic beverages, Patients recovering after a surgery, Severe cardiac, hepatic and renal impairment, Usage of diuretics
Rash, Abdominal pain, Drowsiness, Gas, Allergen, Allergy, Sleepiness weakness, Allergic, Diarrhoea, Headache, Urge to vomit, Brief loss of consciousness, Symptoms due to exposure to sunlight, Dyspepsia, Nausea, Urticaria, Enuresis, Dizziness
Pack (10×10 Tab )